Complementary effects of coenzyme Q۱۰ and Lepidium sativum supplementation on the reproductive function of mice: An experimental study

سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 132

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شناسه ملی سند علمی:

JR_IJRM-19-7_003

تاریخ نمایه سازی: 2 شهریور 1400

چکیده مقاله:

Background: Coenzyme Q۱۰ (CoQ۱۰) and Lepidium sativum (LS) have therapeutic effects on infertility. Objective: To evaluate the combined effects of LS and CoQ۱۰ on reproductive function in adult male NMRI mice. Materials and Methods: Eighty three-months-old male mice (۳۵-۴۰ gr) were divided into ۴ groups   (n = ۱۰/each) of: control (treated with water), CoQ۱۰-treated (۲۰۰, ۳۰۰, and ۴۰۰ mg/kg/body weight), LS-treated (۲۰۰, ۴۰۰, ۶۰۰ mg/kg/body weight), and co-treated (LS [۶۰۰ mg/kg/body weight] + CoQ۱۰ [۲۰۰ mg/kg/body weight]) groups. Serum testosterone, luteinizing hormone, follicle-stimulating hormone, and gonadotropin realizing hormone (GnRH) levels were measured using ELISA method. The sperm quality was assessed using Sperm Class Analyzer® (SCA) CASA system and GnRH mRNA expression levels were evaluated by real-time polymerase chain reaction. Results: The number of sniffing and following behavior was significantly higher in LS-treated (۴۰۰ and ۶۰۰ mg/ml/body weight) groups than the control group (p = ۰.۰۰۰۷ and p = ۰.۰۰۱۰, respectively). The number of mounting and coupling behaviors was significantly higher in the CoQ۱۰ (۳۰۰ and ۴۰۰ mg/ml/body weight)-treated animals than the control group (p = ۰.۰۱۷۰ and p = ۰.۰۰۰۶, respectively). Co-treatment of CoQ۱۰ (۲۰۰ mg/ml/body weight) and LS (۶۰۰ mg/ml/body weight) significantly increased all aspects of sexual behaviors as well as the levels of serum testosterone (p = ۰.۰۰۱۱), luteinizing hormone (p = ۰.۰۰۶۲), and follicle-stimulating hormone (p = ۰.۰۰۰۱); sperm viability (p = ۰.۰۳۰۰) and motility (p = ۰.۰۰۱۰); and GnRH mRNA levels (p = ۰.۰۰۱۶) compared to the control group. Conclusion: The co-administration of CoQ۱۰ and LS significantly improves the activity of the hypothalamic-pituitary-gonadal axis and enhances the reproductive parameters in adult male mice.

نویسندگان

Fatemeh Rahimi Asl

Department of Biology, Islamic Azad University North Tehran Branch, Tehran, Iran.

Maryam Khosravi

Department of Biology, Faculty of Biological Sciences, Islamic Azad University North Tehran Branch, Tehran, Iran.

Ramin Hajikhani

Department of Biology, Faculty of Biological Sciences, Islamic Azad University North Tehran Branch, Tehran, Iran.

Jalal Solati

Department of Biology, Karaj Branch, Islamic Azad University, Karaj, Iran.

Hossien Fahimi

Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.

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