The importance of major butyrate producer bacteria, Faecalibacterium prausnitzii , in inflammatory conditions

Background and Aim : Faecalibacterium prausnitzii (F. prausnitzii) seems to be about ۵% of the fecal microbiota in healthy adults which is one of the amplest bacteria in the human intestinal microbiota of healthy adults. If F. prausnitzii is less in the gut, several disorders would be implicated, such as inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), Colorectal cancer (CRC), obesity, coeliac disease, and diabetes it is still not vivid whether this is a cause or a consequence of these disorders. Most information links plentitude of F. prausnitzii to health in which comes from ۱۶S rRNA based on profiling of microbiota in inflammation. the interaction of this bacterium with inflammation has been studied for several years. inflammation is the main key in initiation and development of cancers and has a crucial role in commencing majority of diseases specially cancer.Methods : About ۶۰ articles were gathered around the world and have been studied carefully. some of the important details were extracted and written in ۲ tables.one is for in vivo experiments and the other table is about in vitro.Results : In in vivo and in vitro conditions, F. prausnitzii could alleviate IL-۱۲, IFN-𝛌, IL-۸, IL-۱۷, TNF-α, IL-۶, and IL-۱۷ levels and on the other hand could increase IL-۱۰ secretion, IL-۱۲p۷۰, TGF-β, surface expression CD۸۳, CD۸۶ and CD۴۰Conclusion : F. prausnitzii and its supernatant have a great anti-inflammatory role and by these anti-inflammatory properties, this bacterium contributes to immune homeostasis in the intestine. Thus, F. prausnitzii can be introduced as next-generation probiotics and treat for inflammatory diseases.

کلیدواژه ها:

Faecalibacterium prausnitzii ، inflammation ، gut microbiota ، anti-inflammatory