Evaluation of drug resistance rate in Acinetobacter baumanii isolated from patients with ventilator-associated pneumonia of ۲۰۱۰ to ۲۰۲۰ in world: A systematic review and meta-analysis

Background and Aim : The high resistance of Acinetobacter baumanii to various antibiotics and the prevalence of multidrug-resistant (MDR) strains make it difficult to control and treat. The aim of this study was of drug resistance in A. baumanii isolated from patient with ventilator-associated pneumonia (VAP).Methods : All articles indexed in international databases (PubMed, Science Direct, Google Scholar, Biological abstracts, ISI web of knowledge and IranMedex) on drug resistance A. baumanii isolated from patient with VAP from ۲۰۱۰ to ۲۰۲۰ were reviewed. The full texts of English and Persian articles related with these subjects were included. Review articles, abstracts, articles in languages other than English and Persian, articles with unknown sample locations were excluded. Data were analyzed using meta-analysis and random effects models with the software package Meta R, Version ۲.۱۳ (p <۰.۰۰۰۱) (confidence interval: ۹۵%).Results : The prevalence of A. baumanii and MDR A. baumanii in VAP patients was ۵۶.۷۴% (p = ۰.۰۰) and ۷۰.۶۸% (P <۰.۰۰۰۱), respectively. Both of them had a significant relationship, with increasing A. baumanii and MDR A. baumanii in VAP patients, rate of A. baumanii infection was increased. The prevalence of A. baumanii in VAP had a significant relationship with the continent (p <۰.۰۰۰۱), Asia with ۴۳.۰۷% and Africa with ۷% had the highest and lowest prevalence, respectively.Conclusion : VAP is of particular importance in the intensive care unit of the hospital. Compliance with infection control standards is essential to prevent and, given the high prevalence of MDR A. baumanii.

کلیدواژه ها:

Drug Resistance ، Acinetobacter baumanii ، Ventilator-Associated Pneumonia