Determination of multi- drug resistant (MDR) and extensively drug-resistant (XDR) clinical isolated Pseudomonas aeruginosa and Acinetobacter baumannii phenotypes in Northeast of Iran

Background and Aim : Multi and extensively drug- resistant, Pseudomonas aeruginosa (PA) and Acinetobacter baumannii (AB) as two main causative agents of nosocomial infections are considered as health threats in hospitalized patients. Choosing a proper antibacterial regime plays a critical role in the prevention and eradication of mentioned bacterial related infections. Evaluation of the MDR and XDR AB and PA frequencies in clinical specimens are the main objectives of this surveyMethods : : In this cross-sectional study, clinical isolates of AB and PA strains were collected using traditional bacteriological tests during ۲۰۱۷-۲۰۱۸. Susceptibility patterns of isolates were assessed by disc diffusion methods according to the Clinical Laboratory Standard Institute (CLSI) guidelines.Results : Out of ۳۲۴۸ clinical samples, AB and PA strains were detected in ۳۰۹(۹.۵۱%) of them, ۹۴ (۳۰.۴۲%) females and ۲۱۵ (۶۹.۵۸%) males. Susceptibility testing indicated that (۱۶.۵۰%) and (۱۵.۵۳%) of the PA and (۷۴.۷۵%) and (۷۳.۱۳%) of the AB isolates were screened as the MDR and XDR strains, respectively. The frequency of MDR isolates was higher in wound samples ۲۲۲ (۷۱.۸%). This rate in Behavioral Intensive Care Unit (BICU) ۱۸۷(۶۰.۵%) and restoration ward ۶۳(۲۰.۴%), were detected respectively. The frequency of XDR isolates in BICU ۱۸۷ (۵۹.۵۴%), restoration ۵۸ (۱۸.۷۷%), and burns ۳۰ (۹.۷۰%) were assessed as well.Conclusion : considering high isolation rates of MDR and XDR AB and PA strains, it is necessary to apply prevention criteria for eradication of the mentioned bacteria from hospital wards.

کلیدواژه ها:

Multi-drug resistant (MDR) ، extensively-drug resistant (XDR) ، Pseudomonas aeruginosa ، Acinetobacter baumannii ، Carbapenem resistant A. baumannii ، nosocomial infections