Effect of Rosa damascena on the Severity of Depression and Anxiety in Postmenopausal Women: A Randomized, Double-blind, Placebo-controlled Clinical Trial

Background: Depression and anxiety as the most common psychological disorders reduce the quality of life in women during menopause. Aim: Given the potential therapeutic properties of Rosa damascena, the present study aimed to investigate the effect of Rosa damascena on the severity of depression and anxiety in postmenopausal women. Method: This clinical trial was conducted on ۱۱۰ postmenopausal women in Tehran, Iran, during ۲۰۲۰. The participants in the intervention group received ۵۰۰ mg dried Rosa damascena capsules, and the control group received placebo capsules three times a day (once every ۸ hours) for ۴۰ days. The data were collected using a demographic characteristics form, Beck's Depression Inventory, Spielberger's State-Trait Anxiety Inventory, and adverse effects questionnaire. Subsequently, the data were analyzed in SPSS software (version ۱۹) through the independent t-test, chi-square, Mann-Whitney, and repeated measures tests. Results: There was no difference in the mean score of depression before and ۲۰ days after the intervention in the intervention group; however, this difference was significant ۴۰ days after the intervention (p <۰.۰۵). The severity of anxiety differed significantly in the intervention group on days ۲۰ and ۴۰ post-intervention (p <۰.۰۰۱); however, these changes were not significant in the placebo group. The mean score of anxiety ۲۰ and ۴۰ days and depression ۴۰ days after the intervention showed a significant difference between the two groups (p <۰.۰۰۱). Implications for Practice: It seems that R. damascena has effects on postmenopausal depression and anxiety. Accordingly, menopausal women are recommended to use R. damascena as an efficient non-pharmacological intervention.  

کلیدواژه ها:

Anxiety ، Depression ، Herbal Medicine ، Menopause ، Rosa damascena