Effect of the Surgery Type, Mastectomy vs. Breast Conserving Surgery, on Outcomes of Patients With Locally Advanced Breast Cancer Receiving Neoadjuvant Therapy
محل انتشار: فصلنامه سرطان پستان، دوره: 4، شماره: 4
سال انتشار: 1396
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 212
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شناسه ملی سند علمی:
JR_ARCHB-4-4_004
تاریخ نمایه سازی: 24 خرداد 1400
چکیده مقاله:
Background: Breast cancer is the most prevalent site-specific cancer and oneof the most frequent causes of cancer death in women worldwide. Neoadjuvantchemotherapy, along with surgical treatment—breast conserving surgery (BCS) ormastectomy—is an important part of treatment for locally advanced breast cancer.As BCS is preferred to mastectomy in terms of cosmetic, quality-of-life, andfunctional outcomes, it would be the preferred treatment for locally advancedbreast cancer (LABC), if its oncological safety is confirmed.Methods: In this study, we retrospectively compared the oncologic outcomesof post-neoadjuvant chemotherapy BCS with mastectomy in ۲۰۲ patients withLABC.Results: There were no significant differences between BCS and mastectomyregarding overall survival, local recurrence, contralateral breast cancer, and distantmetastasis.Conclusions: Our study showed that post-neoadjuvant chemotherapy BCS isan oncologically safe surgical treatment in LABC and that BCS can be consideredas an acceptable treatment in selected patients with LABC.
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نویسندگان
Negar Mashoori
Department of Surgery, Tehran University of Medical Sciences, Tehran, Iran- Kaviani Breast Disease Institute (KBDI), Tehran, Iran
Sanaz Zand
Kaviani Breast Disease Institute (KBDI), Tehran, Iran
Ryan Nazemian
Department of Anesthesiology, University Hospitals, Cleveland Medical Center, USA- Institute for Transformative Molecular Medicine, Case Western Reserve University, USA
Ahmad Kaviani
Department of Surgery, Tehran University of Medical Sciences, Tehran, Iran- Kaviani Breast Disease Institute (KBDI), Tehran, Iran