The role of vitamin D۳ and vitamin B۹ (Folic acid) in immune system

سال انتشار: 1395
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 229

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شناسه ملی سند علمی:

JR_INJER-3-1_010

تاریخ نمایه سازی: 22 خرداد 1400

چکیده مقاله:

Background and aims: Vitamins are essential constituents of our diet that Longley have been known to influence the immune system. Vitamin D۳ and B۹ have received particular attention in recent years as these vitamins have been shown to have an unexpected and crucial effect on the immune response. ۱, ۲۵(OH)۲D۳ metabolizing enzymes and vitamin D receptor (VDR) are present in many cell types including various immune cells such as antigen-presenting-cells, T cells, B cells. Methods: In this mini review, we study ۳۰ novel articles since ۲۰۰۹ to ۲۰۱۵ about the essential roles of vitamins in modulating a broad range of immune processes, such as lymphocyte activation, T-helper-cell differentiation and regulation of the immune response. Results: ۱, ۲۵(OH)۲D۳ has direct effect on CD۴+ T (T-helper) cells for suppressing various cytokines such as IFN-γ, IL-۱۷, IL-۲۱ and IL-۲۲, while enhancing the regulatory Tcells. In vitro studies show that Treg cells could be differentiated from naive T cells in vitamin B۹-reduced condition. Conclusions: These findings provide a new link between diet and the immune system, which could maintain the immunological homeostasis and clarify the beneficial roles of vitamins in informing the design of vitamin analogs as pharmacologic agents for the generation and maintenance of a healthy immune condition.

نویسندگان

Reza Mansouri

Department of Immunology, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran

Maryam Moogooei

Department of Immunology, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.

Mozhgan Moogooei

Department of Immunology, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

Nastaran Razavi

shahrekord University of Medical Sciences, shahrekord, Iran

Amir Hossein Mansourabadi

Department of Immunology, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran

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