Scaffolds Prepared by Nanocomposites of Polyaniline and Poly(۲-hydroxy ethyl methacrylate)-co-Poly(Nisopropylacrylamide)- co-Poly(ε-caprolactone) Terpolymers

Biocompatible, conductive, and hydrophilic ۳D fibroblast scaffolds were prepared by using Poly(۲-hydroxy ethyl methacrylate)-co-poly(N-isopropylacrylamide)-co-poly(ε-caprolactone) (PHEMA-co-PNIPAAm-co-PCL) terpolymers and polyaniline (PANI) nanocomposites. In terpolymer, PHEMA and PNIPAAm segments reflected hydrophilicity and biocompatibility, and PCL led to appropriate mechanical characteristics. Blending of PANI and terpolymer chains led to induction of conductivity to the terpolymer bulk. The morphology, electrical conductivity, biocompatibility, mechanical properties and hydrophilicity of constructed nanofibers were investigated. To this end, the cyclic voltammetry (CV) measurement, field emission scanning electron microscopic (FESEM) images, the contact angle measurement, and the tensile test were conducted. The obtained scaffolds showed natural microenvironment of extra cellular matrix (ECM) to regulate cell attachment, proliferation, and differentiation for electrical conductivity and hydrophilicity. In vitro cytocompatibility investigations represented that nanofibers were non-toxic to mouse fibroblast cells.

کلیدواژه ها:

Fibroblast Scaffold ، Terpolymer ، PANI