Fabrication of Erythromycin loaded Poly vinyl alcohol and Ethyl cellulose polymeric films for wound healing drug delivery
سال انتشار: 1399
نوع سند: مقاله کنفرانسی
زبان: فارسی
مشاهده: 294
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شناسه ملی سند علمی:
CBGCONF07_156
تاریخ نمایه سازی: 9 خرداد 1400
چکیده مقاله:
In this study, we aimed to investigate the efficacy of Polyvinyl alcohol (PVA) and Ethylcellulose (EC) films as
topical wound dressing systems for the sustained release of Erythromycin (EM). The drug loaded PVA and EC films were
characterized by FTIR, and the obtained spectra showed a good dispersion of drug in the polymers without any chemical
reaction. Additionally, mechanical specifications of the prepared formulations were investigated. It was shown that EC
has better swelling behavior in comparison with PVA. The invitro release profiles of EM was recorded at ۲۵˚C. EM has
shown initial burst release from both formulations, lasting ۲۲ and ۴۸ hours for PVA and EC based formulations,
respectively. The results showed that EC has more extended drug release path, and proves to be an efficient drug carrier
for EM.
کلیدواژه ها:
نویسندگان
Nasrin Aliasgharlou
Department of Science, University of Urmia, Urmia, Iran
Farzin Asghari Sana
Solid Tumor Research Center, Urmia University of Medical Sciences, Urmia ،Iran
Pezhman Zolfaghari
Department of Chemical Engineering, Faculty of Chemical and Petroleum Engineering,University of Tabriz,, Iran.