Relationship between PAI۱ promoter ۴G/۵g polymorphism and stroke

PAI-۱ has become recognized as a central molecule linking pathogenesis and progression of thrombotic vascular events, including stroke. Clinical and experimental studies show that PAI-۱ deficiencies cause accelerated fibrinolysis and bleeding, whereas elevated PAI-۱ plasma levels are associated with vascular thrombosis. Raised PAI۱ plasma levels are related to a ۱-bp guanine deletion/insertion (۴G/۵G) polymorphism in the promoter of the PAI۱ gene. The ۴G allele is associated with higher plasma PAI۱ transcription and activity. In the current study, the association of higher PAI-۱ plasma levels and the prevalence of the ۴G/۵G polymorphism in the PAI-۱ gene promoter region in young patients with stroke were explored. Significantly, higher PAI-۱ levels were observed in patients when compared to controls (p =۰۰۲). The ۴G/۵G polymorphisms were significantly associated with increased PAI-۱ levels, with the variant homozygous ۴G/۴G corresponding to mean values in patients versus controls.

کلیدواژه ها:

Stroke ، PAI-۱ ، Polymorphism ، Plasma