miR-۱۴۶a rs۲۹۱۰۱۶۴ polymorphism and lung cancer in a Tehran population

Lung cancer is still the most common cancer worldwide in terms of the number of newly diagnosed cases and mortality rate. The expression of miR-۱۴۶a was reduced in mesenchymal-like lung cancer cell lines. The overexpression of miR-۱۴۶a induced a marked reduction of the mesenchymal marker and increase in the epithelial marker in lung cancer cell lines. The current study investigated the association of miR-۱۴۶a genotypes and lung susceptibility in a Tehran population to determine the visibility of using RFLP-PCR genotype. The results revealed a significantly higher frequency of miR-۱۴۶a CG and CC genotypes (p =۰.۰۱ and p=۰.۰۰۸, respectively) in patients compared with the control group. Those with the miR-۱۴۶a GC and CC genotypes had an increased risk for developing lung cancer (OR=۱.۹; ۹۵% CI: ۱.۱-۳.۳ and OR=۴.۱; ۹۵% CI: ۱.۵-۱۲.۳, respectively). Moreover, the frequency rates of miR-۱۴۶a CC genotype and C allele were significantly higher in patients than in the controls (p =۰.۰۰۶ and p=۰.۰۰۰, respectively).

کلیدواژه ها:

Lung cancer ، MicroRNA ، RFLP-PCR genotype ، epithelial-mesenchymal transition