Relationship between PNPLA۳ Gene rs۷۳۸۴۰۹ Polymorphism and Non-alcoholic Fatty Liver in Mazandaran Province

Nonalcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease. Non-alcoholic fatty liver disease is a spectrum of simple steatosis that is benign to non-alcoholic steatohepatitis (NASH) associated with fibrosis and inflammation. Genetic factors play an important role in this disease. The PNPLA۳ gene (C > G) rs۷۳۸۴۰۹ polymorphism has been defined to be associated with increased liver fat content and liver damage in metabolic disorders. In this study, the association of this polymorphism with non-alcoholic fatty liver disease was investigated in the Mazandaran province population. Our study population consisted of ۸۵ patients and ۸۵ controls. Blood samples were collected from patients and DNA were then extracted by boiling method. Genotypes of this polymorphism were determined by PCR-RFLP method. There was a significant relationship between CG genotype and risk of NAFLD (P = ۰.۰۱۲).

کلیدواژه ها:

PNPLA۳ Gene Polymorphism Non ، alcoholic