Thr Expression Profile Evaluation of MIR-۱۲۵B as a Common MiRNAs Between Tuberculosis and Non-Small Cell Lung Cancer

Background and Aim: Background and Aim: Worldwide, lung cancer specifically Non-Small Cell Lung cancer (NSCLC) is one of the most preventable and common types of cancer. Also, Tuberculosis (TB) disease is a major global public health threat and is one of the most important infectious diseases throughout history in the world. Having TB before lung cancer increases mortality rates and significantly correlates with mortality due to lung cancer. TB and lung cancer have similar symptoms, and tuberculosis has symptoms similar to malignancy, so Sometimes its diagnosis confused with lung cancer. The miRNAs are biological molecules that play critical regulatory roles in the physiological and pathological processes. In several types of research many miRNAs have been studied which showed the alternation of expression in TB and NSCLC separately. In this research paper, the expression of mir-۱۲۵b was examined which is altered in both TB and NSCLC commonly.Methods: Method: ۳۰ patients with NSCLC, ۳۰ patients with TB and ۳۰ healthy individuals were contributed to this research. The expression pattern of mir-۱۲۵b was evaluated and compared in TB and NSCLC patients with healthy controls, using Real-Time PCR method.Results: Results: As a result, the expression of mir-۱۲۵b was lower in both TB and NSCLC patients than healthy controls. Conclusion: Conclusion: Therefore, mir-۱۲۵b can be used as a diagnostic and prognostic biomarker in TB and NSCLC diseases. The expression pattern of this miR could be useful to follow up on the biological pathways which have essential roles in these diseases.

کلیدواژه ها:

expression profile ، mir-۱۲۵b ، Tuberculosis ، Non-Small Cell Lung cancer.