Changes expression of TMEM۱۶A in infertile men with sperm motility problems

Background and Aim: Motility and morphology of sperm can effected on fertilization, TMEM۱۶A recognized as a type of ionic channel that work as a Ca۲+-activated Cl channels and have important role as a part of transmembrane system. This gene has interference in many vital mechanisms in cell functions. TMEM۱۶A have change expression in infertile male. The present study aims to measure the expression of TMEM۱۶A and its correlation with sperm motility.Methods: We selected ۳۲ men with Asthenozoospermia and ۳۴ cases with Normozoospermia based on the clinical criteria. The expressions of TMEM۱۶A in the spermatozoa were evaluated by qRT-PCR. For analyzing, kruskal-wallis test was used to compare the expression of these in the studies groups.Results: Expression of TMEM۱۶A in Asthenozoospermia group showed significant (p<۰.۰۵) decrease expression compare with control group. Our correlations analysis between TMEM۱۶A expressions with sperm parameters including normal sperm morphology and sperm motility showed a significant positive result with sperm motility in Asthenozoospermia group.Conclusion: our analysis results suggest the probable role of TMEM۱۶A in sperm motility and sperm normal morphology and can interference in male infertility. Supplementary studies can reveal other aspect of TMEM۱۶A role in male infertility.

کلیدواژه ها:

Asthenozoospermia ، infertility ، sperm motility ، TMEM۱۶A