Histopathological and Serological Findings of Lung, Liver and Heart in a Patient with Corona Virus Disease-۲۰۱۹ (COVID -۱۹): A Case Report

سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 397

فایل این مقاله در 6 صفحه با فرمت PDF قابل دریافت می باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:

شناسه ملی سند علمی:

JR_ZUMS-29-134_008

تاریخ نمایه سازی: 11 اردیبهشت 1400

چکیده مقاله:

This study aimed to report histopathological features and serological outputs of the lung, heart and liver in a patient suffered from Coronavirus disease-۲۰۱۹ (COVID-۱۹). A woman was admitted to the Razi Hospital, Rasht city, Iran with the symptoms of cough, dyspnea, fever and myalgia. She had also Parkinson’s disease (PD); she had no history of respiratory, cardiovascular, renal and gastrointestinal diseases and alcohol consumption. COVID-۱۹ infection was proved by the Real time-PCR (RT–qPCR) test. The required specimen was obtained from nasopharyngeal swab; however, lung radiologic findings revealed atypical signs of COVID-۱۹. The patient expired after ۸ days of admission. After death, needle biopsy was performed for histopathologic evaluation of the heart, lung and liver tissues. The RT–qPCR was performed to evaluate the presence of Coronavirus in the tissues. The pathological biopsies showed advanced alveolar damages in the lung, periportal inflammation in the liver, spread steatosis in the hepatocytes and moderate myocarditis in the heart. However, the RT-qPCR test was negative for these tissues, but alterations in the above-mentioned areas may be due to the secondary side effects of COVID-۱۹ infection or pharmacological treatments.

کلیدواژه ها:

نویسندگان

Erfan Naseri

Student Research Committee, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran

Fahimeh Mohammadghasemi

Cellular & Molecular Research Center, Guilan University of Medical Sciences, Rasht, Iran

Fahimeh Shams

Student Research Committee, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran

Sina Saliminasab

Student Research Committee, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran

Paridokht Karimian

Dept. of Pathology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran

Morteza Rahbar Taramsari

Dept. of Forensic Medicine, School of Medicine, Guilan University of Medical Sciences. Rasht, Iran

Siroos Kordrostami

Razi Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran

Ali Alavi Foumani

Inflammatory Lung Diseases Research Center, Dept. of Internal Medicine, Razi Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran

Hossein Hemmati

Dept. of General Surgery, Division of Vascular Surgery, Guilan University of Medical Sciences, Rasht, Iran

Seyed Amineh Hojati

Gastrointestinal and Liver Diseases Research Center (GLDRC), Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran

Pirouz Samidoust

Dept .of General Surgery, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran

Masoumeh Faghani

Cellular & Molecular Research Center, Guilan University of Medical Sciences, Rasht, Iran

مراجع و منابع این مقاله:

لیست زیر مراجع و منابع استفاده شده در این مقاله را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود مقاله لینک شده اند :
  • Huang C, Wang Y, Li X,et al. Clinical features of ...
  • Bai Y, Yao L, Wei T,et al. Presumed asymptomatic carrier ...
  • Long B, Brady WJ, Koyfman A, Gottlieb M. Cardiovascular complications ...
  • Fan Z, Chen L, Li J,et al. Clinical features of ...
  • Simpson S, Kay FU, Abbara S,et al. Radiological society of ...
  • Li YC, Bai WZ, Hashikawa T. The neuroinvasive potential of ...
  • Akhmerov A, Marbán E. COVID-19 and the heart. Circ Res. ...
  • Manolis AS, Manolis TA. Cardiovascular complications of the coronavirus (COVID-19) ...
  • Chai X, Hu L, Zhang Y,et al. Specific ACE2 expression ...
  • Bonilla-Palomas JL, Gámez-López AL, Moreno-Conde M,et al. Hypoalbuminemia in acute ...
  • Bernstein HG, Dobrowolny H, Keilhoff G, Steiner J. Dipeptidyl peptidase ...
  • Scorza FA, Fiorini AC, Scorza CA, Finsterer J. Cardiac abnormalities ...
  • نمایش کامل مراجع