The Implementation of Eight Weeks of Endurance Training and Lithium Chloride Administration on Brain-Derived Neurotrophic Factor (BDNF) Serum Levels in Rats with Alzheimer's Disease

Background and Objective: Alzheimer is a neurodegenerative disease in which a reduced memory capacity and numerous changes occur in the patient’s brain. This study was embarked to shed light on the effects of eight weeks of endurance training and lithium chloride administration on brain-derived neurotrophic factor serum levels in female rats with Alzheimerchr('۳۹')s disease. Materials and Methods: ۷۰ female Sperag Dawley rats were randomly divided into seven groups including: ۱.control, ۲. Sham, ۳. littium chlorid[d۱] e ۲۰, ۴. littium chloride ۴۰, ۵. Endurance training, ۶. Endurance training littium chloride ۲۰, ۷. Endurance training and littium chloride ۴۰. Alziemer was induced in rats by methyl chloride,. Groups of endurance training, endurance training plus littium coloride ۲۰ and endurance training plus littium chloride ۴۰ ran on a treadmill with no incline at the speed of ۱۵ to ۲۰ meters per minute for ۱۵ to ۳۰ minutes each session and five times for eight weeks. The groups of littium coloride ۲۰, endurance training and littium coloride ۲۰ received littium coloride ۲۰ mg/kg according to their body weight per day. The littium coloride ۴۰, endurance training and littium coloride ۴۰ received  littium coloride ۴۰ mg/kg of their body weight per day for ۱۴ days.  During this period, the control group did not have any activity and did not recieve any treatment. ANOVA and tukey post hoc[d۲]  tests were used for statistical analysis. Results: The results showed that lithium chloride as well as endurance training along with their  interactive effects increased levels of brain-derived neurotrophic factor poisoning by neurotoxins. But the greatest impact was observed in endurance training and lithium chloride ۲۰. Also, serum levels of brain-derived neurotrophic factor significantly decresed owing to Methyltin[d۳]  poisoning in female rats (p<۰.۰۵). Conclusion: Based on these findings, we conclude that lithium chloride, endurance training and their interactive effects in female rats with Alzheimerchr('۳۹')s disease raised brain-derived neurotrophic factor serum levels which implies that Alzheimerchr('۳۹')s disease can be improved.

کلیدواژه ها:

Key words: Alzheimer Disease ، Exercise ، Lithium Chloride ، Brain-Derived Neurotrophic Factor ، Rats