Organic base-grafted on magnetic nanoparticles as a recoverable catalyst for the green synthesis of hydropyridine rings

Organic-inorganic hybrid materials are of great interest as heterogeneous catalysts in organic synthesis, due to the functional diversity merged with thermal and mechanical stability of inorganic solids.1 1,4-Dihydropyridines (1,4-DHPs) are valuable heterocyclic compounds in view of pharmaceuticals and drugs development. 2 As part of our continuous effort to develop efficient heterogeneous magnetic nanocatalysts and green organic reactions 3, herein we describe the synthesis and characterization of 4-aminoquinaldine-grafted magnetite nanoparticles (MNPs-AQ) to give access to biologically interesting 1,4-dihydropyridines as a new eco-friendly method (Scheme 1). This newly design catalyst fulfilled our endeavor toward a heterogeneous system with a green synthetic aspects by avoiding the use of hazardous conditions for accessing target heterocyclic compounds.

کلیدواژه ها:

1 ، 4-dihydropyridines ، polyhydroquinoline ، green chemistry ، hybrid nanoparticles