Synthesis of piperazines derivatives by DABCO bond cleavage

Piperazine rings, as the main skeleton, play an essential role in the structure of many pharmaceutical and agronomic compounds. Also, these heterocyclic structures have been used as pesticides for the treatment of intestinal infections.1 In addition to these structures, dithiocarbamate compounds have been used as fungicides for many years, and nowadays many scientists have taken note of their medicinal and biological properties.2 Here in, we investigated the synthesis of substituted piperazine derivatives at positions 1 and 4 by using the breaking reaction of the C-N bond of the DABCO ring by dithiocarbamates as a nucleophile and various piperazine derivatives were synthesized in good to excellent yields.

کلیدواژه ها:

Dithiocarbamate ، DABCO bond cleavage ، Piperazines