Synthesis of novel UiO-66-SO3H: Application in the synthesis of N-heterocycle compounds via vinylogous anomeric based oxidation
محل انتشار: بیست و هفتمین کنفرانس شیمی آلی ایران
سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 298
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شناسه ملی سند علمی:
ISOC27_146
تاریخ نمایه سازی: 19 اسفند 1399
چکیده مقاله:
Nowadays, one-pot multicomponent coupling reactions (MCRs) have been proven to be a very elegant and rapid way to access complex structures in a single synthetic operation from simple building blocks. They also address fundamental principles of synthetic efficiency and reaction design, and show atom-economy and selectivity [1]. In this context, Hantzsch reaction for the synthesis of dihydropyridines (DHPs) shows interesting features of MCRs . More than a century ago, the first 1,4-DHPs were reported by Hantzsch [2]. After that a number of modified methods under improved conditions have been reported [3]. Hantzsch 1,4-dihydropyridine derivatives are often regarded as the models of the natural reduced nicotinamide-adenine dinucleotide (NADH) coenzyme which functions as redox reagent in the biological metabolism [4]. We have synthesized new UiO-66 containing sulfonic acid tags as catalyst for the regioselective synthesis of highly substituted 2-pyridones. A multicomponent reaction involving ethylcyanoacetate, aromatic or heteroaromatic aldehydes and amines to afford the hexasubstituted 2-pyridones in the presence of described catalyst (Scheme 1).
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نویسندگان
Somayeh Molaei
University of Kurdistan, Department of Chemistry, Faculty of Science, Sanandaj, Iran
Mahmoud Zarei
Department of Organic Chemistry, Faculty of Chemistry, Bu-Ali Sina University, Hamedan ۶۵۱۷۸۳۸۶۸۳, Iran.
Hassan Sepehrmansourie
Department of Organic Chemistry, Faculty of Chemistry, Bu-Ali Sina University, Hamedan ۶۵۱۷۸۳۸۶۸۳, Iran.
Mohammad Ali Zolfigol
Department of Organic Chemistry, Faculty of Chemistry, Bu-Ali Sina University, Hamedan ۶۵۱۷۸۳۸۶۸۳, Iran.
Mohammad Ghadermazi
University of Kurdistan, Department of Chemistry, Faculty of Science, Sanandaj, Iran