Solvent-free, facile, and an efficient synthesis of α-aminonitriles employing Halloysite nanotubes as an ecofriendly cyanating agent

Synthesis of α-aminonitriles1 has been an area of current interest for chemists as well as biologists because these are versatile precursors for the synthesis of pharmacologically significant molecules such as α-amino acids, amides, diamines, and various nitrogen and sulfur containing heterocycles such as thiadiazoles, imidazoles, etc.2–5 Other biologically significant compounds such as saframycin A a natural product and phthalascidin a synthetic analogue, exhibit potent anti-tumor activity. Bruylants reaction and its Barbier version further crowned Strecker products as they serve as intermediate for the production of a variety of potent short-acting opioid analgesics. Halloysite nanotubes (HNTs) are clay minerals with a hollow nanotubular structure. Functionalized halloysite constitutes a valuable support for metal nanoparticles, promoting catalytic applications with tunable properties. Moreover, the presence of an empty lumen opens new perspectives for the production of nanoarchitectures with synergistic catalytic effects, due to the increase in local concentrations and confinement. The main focus of this review is the research on modified halloysite nanotubes for the preparation of an efficient synthesis of α-aminonitriles.

کلیدواژه ها:

Multicomponent reactions ، α-Aminonitriles ، solvent-free ، Heterogeneous catalyst