Regio- and diastereoselective synthesis of pyrazolo[4,3-e]pyridines via multicomponent domino aza-Diels–Alder reactions in water

Aza-Diels–Alder reactions (ADARs) are powerful processes that provide N-heterocycles in a straightforward method. Herein, we report a novel and efficient strategy for the synthesis of pyrazolo[4,3-e]pyridines 5 via a one-pot multicomponent intramolecular ADARs among benzoylacetonitrile derivatives 1, phenylhydrazine 2, salicylaldehyde derivatives 3, and styrenesulfonyl or cinnamoyl chloride 4 in H2O as a solvent.1 Remarkable factors such as green, higher yields, regio- and diastereoselectivity, high atom-economy and easy isolation procedures are key features of this protocol.2,3

کلیدواژه ها:

5-Amino-pyrazole ، Aza-Diels–Alder reactions ، Regio- and diastereoselective