Synthesis of new derivatives of 2-amino-4H-pyran via three-component reaction

Multi-component reaction (MCR) can provide simplicity by reducing the synthesis steps and avoiding complicated purification processes 1. In addition, it has high atom-economy and high selectivity, while saving time, energy and preventing the waste of reagents and solvents2. MCR is widely used for the synthesis of heterocyclic compounds such as 2-amino-4H-pyrans3 and pyrano[3,2‐c]pyran‐5(4H)‐one4. In continuation of our research in the synthesis of bioactive heterocyclic compounds5, herein, we report synthesis of new derivatives of 2-amino-4H-pyran 4a-l using some α-ketoesters 1a-b, active methylene 2a-b, and OH-acids 3a-d in the presence of piperidine (Scheme 1).

کلیدواژه ها:

Multicomponent reactions ، 2-Amino-4H-pyrans ، OH-acids ، α-Ketoesters ، Active methylenes