Synthesis of 3,4-dihydropyrimidine-2(1H)-one derivatives in the presence of nano-catalyst Fe3O4/SiO2/SO3H

The heterogeneous acid catalysts were introduced owing to their unique properties such as ease of separation and recovery, low toxicity and non-corrosive nature from the viewpoint of green chemistry.1 The use of recyclable solid acids in organic reactions is often considered to follow the principles of green chemistry since these catalyzed processes consume less energy and reagents, and minimize waste.2,3 Moreover nanostructured solid acids exhibit higher activity and selectivity than their corresponding bulk materials.4 Herein, we report the synthesis 3,4-dihydropyrimidine-2(1H)-ones (4) from the reaction between aromatic aldehyde (۱) Ethyl acetoacetate (2) and Urea (3) in the presence of nano-catalyst Fe3O4/SiO2/SO3H NPs (Fig.1). The Fe3O4/SiO2/SO3 NPs were thoroughly characterized by using SEM and FT-IR. The results showed that the catalyst has a high activity, is environmentally friendly, heterogeneous and easy to recover from the reaction mixture without losing its catalytic activity.

کلیدواژه ها:

Multicomponent reactions ، Green chemistry ، Nano-catalyst ، Solid acid ، Fe3O4/SiO2/SO3H.