Synthesis of polyoxyethylene-crosslinked polystyrene network for preparation organic support via ATRP technique

Solid-phase organic synthesis (SPOS) continues to beimportant in the development of libraries of new molecules 1. Microporous PS-DVB, with its high thermal stability, chemical inertness, and mechanical robustness, is an attractive support for solid-phase synthesis2. A drawback of the grafting approach, however, is that it reduces the functional group-to-mass ratio (polymer loading) by decreasing the number of free chloromethyl groups while increasing the resin mass. Replacing DVB with R,ω-bisfunctionalized PEG as the cross-linking agent represents a particularly intriguing approach as the propertiesof polymer networks are significantly influenced by thenature of the network junctions 3.In the present study, a surface-initiated ATRP technique was used for the polyaddition of styrene monomer in the presence of a polyethylene glycol (PEG)-derived comonomer/crosslinker (α,ω-bis-4-(vinylbenzyl)ether of polyoxyethylene, denoted with STP) and the nanoparticles with anchored BnCl as the reaction initiator (Figure 1). The thermal behaviors of CPS and CPS/SNPꞌs networks were thoroughly investigated by thermogravimetric analysis (TGA) and differential thermal analysis (DTA).

کلیدواژه ها:

solid-phase organic chemistry ، polystyrene networks ، polyoxyethylene units ، surface-initiated ATRP technique