Modification of Chitosan with Enrofloxacin

Enrofloxacin (EF) is a fluoroquinolone antibiotic used in veterinary against both Gram negative and positive bacteria. It is generally administered at high concentrations which can cause molecular stacking and crystal formation affecting many organs with undesirable side effects. Recently, loading of biologically active compounds on biocompatible polymers has attracted great deals of attention to increase their efficiency in low loading. In continues of our interest in deposition of drugs on polymers,1-3 herein enrofloxacin anchored to chitosan to obtain new polymer supported enrofloxacin for biological applications. The reaction was carried out via amidation reaction between amine groups of chitosan and carboxylic acid group of enrofloxacin. The new compound was characterized with common instruments such as FT-IR, elemental analysis, and energy dispersive spectroscopy.

کلیدواژه ها:

Enrofloxacin ، Chitosan ، Drug delivery