One-Pot Synthesis of 2,4,5-Trisubstituted Imidazoles by using Magnetic Cobalt Ferrite Nanocomposite Supported by Tungstic Acid as a Novel Catalyst

Imidazole and its derivatives are an important group of five‐membered nitrogen heterocyclic compounds, which usually play important roles for the synthesis of natural products and as therapeutic agents.1-3 In particular, 2,4,5-trisubstituted imidazoles are biologically active and found in structures of anti-inflammatory,4 anti-microbial,5 analgesic,6 etc. Herein, we report one-pot synthesis of 2,4,5-triaryl-1H-imidazoles (4) from the condensation reaction of 1,2-diketone (Benzyl, 1mmol)(1), Aldehydes (1mmol)(2) and Ammonium acetate (2mmol)(3) in the presence of solvent by using CoFe2O4@SiO2@WO4H as a novel catalyst that provides required acidic conditions in addition of increasing the efficiency and reaction speed without the need of using harmful acidic catalysts under ultrasound irradiation at room temperature. The structure of synthesized derivatives was deduced from their FT-IR and 1H NMR spectral data and checking melting point.

کلیدواژه ها:

Imidazole ، One-Pot ، Condensation reaction ، Ultrasound irradiation