Ginger Supplementation in Adjunct with Non-surgical Periodontal Therapy Improve Biomarkers of Stress Oxidative, Metabolic Factors and Periodontal Indices in Patients with Type 2 Diabetes Mellitus (DM) and Chronic Periodontitis. A Double-Blind, Placebo-Controlled Trial

Background: The objective of this study was to investigate the effects of ginger supplementation in adjunct with non-surgical periodontal therapy (NSPT) on biomarkers ofstress oxidative, metabolic and periodontal parameters in patients with type 2 DM (T2DM) and chronic periodontitis (CP). Methods: In this double-blind clinical trial study, 50 T2DM patients with CP were randomly allocated to intervention and control groups and received either 2g ginger or placebo (4 tablets) twice a day for 8 weeks. All subjects underwent NSPT during the intervention period. Fasting blood glucose (FBG), glycosylated hemoglobin levels (HbA1c), triglyceride (TG), total cholesterol (CHOL), high-density (HDL-c) and low-density lipoprotein (LDL-c) cholesterol, very low-density lipoprotein (VLDL-c), Total antioxidant capacity (TAC), Malondialdehyde (MDA), clinical attachment loss (CAL), Pocket depth (PD), plaque index and bleeding on probing (BOP) were measured in all subjects at baseline and post-intervention. Independent sample t-test was used to compare the results between two groups. Paired sample t-test was also used to compare the results within groups post-intervention. Results: A significant reduction (p < 0.05) was observed in the mean levels of HbA1c, FBG, MDA, CAL and PD in the intervention group post-intervention. There were no significant differences found in the mean levels of TG, CHOL, LDL-C, VLDL, TAC, plaque and BOP in intervention group post-intervention. The mean serum levels of HDL were significantly increased in the intervention group post-intervention (p < 0.05). There were significant differences observed in the mean changes of HbA1c (-0.75 ± 1.17 and -0.16 ± 0.44; P = 0.04),HDL (3.95 ± 8.54 vs -0.76 ± 5.04; P = 0.03), CAL (-0.57 ± 0.50 vs -0.14 ± 0.35; P = 0.003) and PD (-0.52 ± 0.51 vs - 0.19 ± 0.51; P = 0.04) between intervention and control groups after the intervention. Conclusion: It is recommended that ginger supplementation along with NSPT may be effective in control of the glycemic, lipid, antioxidant and periodontal status in T2DM with CP.

کلیدواژه ها:

Type 2 diabetes mellitus ، Periodontal disease ، Ginger ، Lipid profile ، Glycemic control ، Antioxidant status.