Intravascular brachytherapy with Iridium 192 dosimetry

Introduction & Objectives: The most important cause of death in the world and Iran is coronary heart disease. Considering the importance of treating stroke in preventing myocardial infarction, nuclear medicine has suggested several methods, the most effective being coronary artery brachytherapy. Brachytherapy is a completely localized irradiation to a tumor tissue by one or more radioactive closed springs. It is important to calculate the dose received from cells and tissues to ensure unauthorized radiation is received. Therefore, the purpose of this study was to simulate the presence of electrons in adjacent tissues of the treated vessels.Materials & Methods: The MCNP or Monte-Carlo method was used to estimate the radiation dose distribution around the Iridium 192 radioactive source. The standard ORNL phantom and human vein were selected for this aim. The amount of dose received from the irradiation of a photon source with an average energy of about 0.38 MeV in the phantom and vessel simulation environment was investigated.Results: The findings indicate the significant presence of electrons due to the interaction of photons with matterand a high dose is absorbed outside the vascular tissue.Conclusion: According to the evaluations in the phantom environment for intravascular simulation, it was observed that the highest absorbed dose occurs outside the vein tissue. In evaluating absorbed dose, the importance of electrons in photon sources with biologically damaging effects should never be overlooked.

کلیدواژه ها:

Brachytherapy ، Iridium 192 ، MCNP method ، Myocardial infarction