Effect of flaxseed and chamomile extract on concentration of some biochemical serum factors in rats with experimental gastric ulcer

سال انتشار: 1399
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 220

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شناسه ملی سند علمی:

ICIBS01_230

تاریخ نمایه سازی: 2 آذر 1399

چکیده مقاله:

Introduction and Objectives: Non-steroidal anti-inflammatory drugs (NSAIDS) are used in the treatment inflammatory diseases and these medications can sometimes have various side effects. It has been shown that some herbs can reduce or improve the side effects of these drugs. This study was performed to investigate the effects of chamomile and flaxseed extracts on biochemical factors (Glucose, Potassium, Urea, Calcium, Phosphorus, Sodium, Copper) after induction of indomethacin gastric ulcer in 5 groups of adult male rats. These groups were: negative control group (C), group with 50ml dose of the plant extract (5TE), group with 200ml dose (20TE), group with 500ml dose (50TE), positive control group (In).Materials and Methods: In this study, 30 male Wistar rats were used. The treated rats received extracts toward body weight by Gavage method for 14 days. At the end of treatment, gastric ulcer was induced by indomethacin at a dose of 30 mg for one day. Four hours after induction of gastric ulcer, rat’s blood was collected and biochemical factors of all groups were evaluated.Results: The results showed that Glucose, Copper and Potassium values of the 50TE group did not change significantly compared to the other groups. The amount of Urea in group 50TE is significantly reduced compared to group C. Calcium levels in the 5TE and 20TE groups did not change significantly, but in the 50TE group, there was a significant decrease compared to group C.Conclusion: The combination of Chamomile and flaxseed extract can have a protective effect against gastric ulcer and changes in serum biochemical factors with its antioxidant properties.

نویسندگان

Seyed Mahdi Banan Khojasteh

Associated professor, Department of Biology, Faculty of Natural Science, University of Tabriz, Tabriz, Iran

Saniya Akbary Dibavar

Department of Biology, Faculty of Natural Science, University of Tabriz, Tabriz, Iran