Anti-tumor effects of NDV in a female Doberman with lymphoma cancer

Introduction & Objectives:Newcastle disease (ND) is a highly contagious and fatal disease of poultry caused by Newcastle disease virus (NDV) which is classified under the genus Avulavirus within the family paramyxoviridae . NDV is an enveloped, single stranded negative-sense RNA virus whose genome is approximately 15 kb, Its genome has six open reading frames (ORFs) which encode for six major structural proteins, namely, nucleoprotein (NP), phosphoprotein (P), matrix protein (M), fusion protein (F), hemagglutinin-neuraminidase (HN), and the RNA-dependent RNA polymerase (L), The cleavability of the fusion protein precursor (F0) and the presence of a number of basic residues in the fusion protein cleavage site are major determinants for NDV pathogenecity as lentogenic, mesogenic and vellogenic, The apoptosis induction and anti-metastatic of malignant cancer cells by NDV carried out by F0 protein .La Sota strain is a mesogenic NDV and genetically similar to wild NDV, RRQRRF motif isolated from Iranian farms.Materials & Methods: In current report a female 40 moths Doberman dog with some pathognomic signs of lymphoma and positive laboratory tests were candidate for NDV therapy as anti-tumor at 2019 April. The animal treated by supportive and antibiotics treatments and suitable nursing, the lyophilized La Sota NDV strain vial were prepared from Razi Institute (RVSRI) and used in 5 to 10 times of vaccinal dose (106 EID50 ) in 5 ml PBS as parenteral injection with interval of 3 days for a period of 15 days.Conclusion: Regarding to laboratory exams and clinical sign the lymphoma were controlled and no any metastatic tissues detected in the studied Doberman.

کلیدواژه ها:

NDV ، Anti tumor ، Lymphoma ، Dog