in silico study of association of rs35613052 with hsa-miR-770-5p in acute leukemia

FLT3 overexpression is a recurrent event in various acute leukaemia subtypes. This transcriptional deregulation is important to define the prognostic risk for many patients. Collectively, the results of previous studies showed that the overexpression of FLT3 is a potential risk factor in leukemia. In this study, we predicted by use of mirbase, mirtarbase, mirwalk, ncbi, david, mirnasnp and genemania databases. In a study of the KeGG signaling pathway and pathways in cancer, we found FLT3 gene that led to cancer. we predict hsa-miR-770-5 targets A allele in rs35613052 of FLT3gene more than G allele. Therefore, it is expected With The presence of G allele in rs35613052, hsa-miR-770-5p have less binding and inhibitory effect. Therefore, gene expression in these individuals with the G allele is predicted to increase and we expect the G allele to be more common in sick people. Therefore, given the oncogenic role of the gene and the kegg pathway, it is expected to be less common frequent in patients with the A allele.

کلیدواژه ها:

FLT3 ، rs35613052 ، hsa-miR-770-5p ، AML ، ALL