New insights into structural systems biology

Systems biology is a biology-based interdisciplinary field of study that focuses on the behavior and interactions of biological entities, including organisms, organs cells and macromolecules. The main goal of this field of study is using computational and mathematical tools for discovery of complex interactions within biological systems. Proteins are ubiquitous building blocks in biological systems and the dynamic networks of protein interactomes can be valuable for inferring the global features of any cellular machinery. Structural systems biology is identified as modelling protein interactions which is going to draw a molecular picture of cell. The most-critical aspects of how a biological process works results from the cooperative behavior of many types of proteins, all acting together in complexes. This places the experimental and computational aspects of structural systems biology in a critically significant position for systems biology. Most researchers have focused on two critical points of structural systems biology. In the first part, we are trying to find out the complexity of protein-protein interactions as the global features of a cell network. In the second part, we are considering proteins as a unified system of hundreds of amino acids empowers us to predict the effect of a small change on the whole system. This approach has many applications, e.g. in precision medicine. In this study, we will review all new aspects of these two fields of study in structural systems biology. We also discuss different experimental techniques and computational tools for improving our basic understanding of biological systems using structural systems biology.

کلیدواژه ها:

Systems biology ، structural systems biology ، biological systems ، protein interactomes ، dynamic networks of protein