A New Approach in AdvancedWound Care by Replacement of ChemicalAntibacterial AgentsWith Natural Herbal Drug Extracts in a NanoWound Dressing

Wounds are one of themost important issues in wound treatment that negatively affects the quality of lifeand their proper treatment has been very much considered. Delay in wound healing, especially wounds caused bydiseases such as diabetes, obesity and cancer, is one of the key issues that are currently being addressed by scientificresearches. As the protective layers of skin during the injury get damaged the microbial and bacterial agents invadethe wound area and it became infected. For resolving this problem chemical antibacterial agents such as Silver,Iodine, Tetracycline Hydrochloride and other chemical agents are loaded into the matrix of wound dressings. Butthese chemicals have side effects and environmentally are not healthy and show some poisonous effects. Thepurpose of this study was to evaluate antibacterial activity of natural antibacterial agents such as herbal drug extractsby loading theminto matrix of wound dressing.To do this, a typical nano wound dressing ismade by electrospinningof a FDA approved material like Cellulose Acetate. Therefore different concentrations of this compound were testedto achieve an electrospinable solution and then regarding the total volume of solution a partial volume of a typicalantimicrobial herbal drug extract like Thyme was added into the solution and the final solution was electrospun.Antibacterial test and other invitro analysis showed that this new wound dressing had a proper antibacterial activityagainst the common bacteria’s like Staphylococcus aureus and Escherichia coli. morphological analysis showed thatthis fiber wound dressing had a nano structure. Therefore this can be concluded that loading antibacterial herbal drugextract into the matrix of wound dressing can be a good substitution for chemical compounds