Effects of selenium supplementation on glucose homeostasis in women with gestational diabetes mellitus: A randomized, controlled trial

سال انتشار: 1398
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 565

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شناسه ملی سند علمی:

JR_IJRM-18-1_007

تاریخ نمایه سازی: 29 اسفند 1398

چکیده مقاله:

Background: There is limited evidence about the anti-diabetic effects of seleniumsupplementation in women with gestational diabetes mellitus (GDM).Objective: This study investigates the effects of selenium supplementation on glucosehomeostasis in women with GDM.Materials and Methods: A total of 60 pregnant women with GDM were enrolled in thisprospective randomized, double-blind, and placebo-controlled clinical trial. They wererandomly assigned to take either 100μg selenium supplements as tablet or a placebodaily for 12 wk since 24-28 wk of gestation. The primary outcomes were changes in theglucose homeostasis, including fasting plasma glucose, the 2-hr post prandial bloodglucose, serum insulin level, glycosylated hemoglobin (Hb A1C), and the homeostasismodel assessment of insulin resistance(HOMA_IR) at the initial period and 3 monthsafter intervention.Results: The mean maternal age of the patients who took selenium supplements was29.19 ± 6.16 (range 18-41) years. In the placebo group, the mean maternal age was 31 ±4.43 (range 24-39) years. Compared with the placebo group, fasting plasma glucose, 2-hr post-prandial blood glucose, glycosylated hemoglobin(Hb A1C), serum insulin level,and homeostasis model of assessment-estimated insulin resistance(HOMA_IR) werenot significantly changed in the selenium group at the end of study (p = 0.25, p = 0.87,p = 0.34, p = 0.57, and p = 0.31, respectively).Conclusion: The results of this trial suggest that supplementation with 100μg ofselenium does not modulate glucose homeostasis in women with GDM.

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نویسندگان

Fatemeh Sadat Najib

M.D, Infertility Research Centere of Obstetrics and Gynecology Ward, Shiraz Medical School, ShirazUniversity of Medical Sciences, Shiraz, Iran

Tahereh Poordast

M.D, Infertility Research Centere of Obstetrics and Gynecology Ward, Shiraz Medical School, ShirazUniversity of Medical Sciences, Shiraz, Iran

Mina Rezvan Nia

M.D, Infertility Research Centere of Obstetrics and Gynecology Ward, Shiraz Medical School, ShirazUniversity of Medical Sciences, Shiraz, Iran

Mohammad Hossein Dabbaghmanesh

M.D, Endocrin and Metabolic Research center of Internal Medicine Ward, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran