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Effects of selenium supplementation on glucose homeostasis in women with gestational diabetes mellitus: A randomized, controlled trial

عنوان مقاله: Effects of selenium supplementation on glucose homeostasis in women with gestational diabetes mellitus: A randomized, controlled trial
شناسه (COI) مقاله: JR_IJRM-18-1_007
منتشر شده در شماره 1 دوره 18 فصل در سال 1398
مشخصات نویسندگان مقاله:

Fatemeh Sadat Najib - M.D, Infertility Research Centere of Obstetrics and Gynecology Ward, Shiraz Medical School, ShirazUniversity of Medical Sciences, Shiraz, Iran
Tahereh Poordast - M.D, Infertility Research Centere of Obstetrics and Gynecology Ward, Shiraz Medical School, ShirazUniversity of Medical Sciences, Shiraz, Iran
Mina Rezvan Nia - M.D, Infertility Research Centere of Obstetrics and Gynecology Ward, Shiraz Medical School, ShirazUniversity of Medical Sciences, Shiraz, Iran
Mohammad Hossein Dabbaghmanesh - M.D, Endocrin and Metabolic Research center of Internal Medicine Ward, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran

خلاصه مقاله:
Background: There is limited evidence about the anti-diabetic effects of seleniumsupplementation in women with gestational diabetes mellitus (GDM).Objective: This study investigates the effects of selenium supplementation on glucosehomeostasis in women with GDM.Materials and Methods: A total of 60 pregnant women with GDM were enrolled in thisprospective randomized, double-blind, and placebo-controlled clinical trial. They wererandomly assigned to take either 100μg selenium supplements as tablet or a placebodaily for 12 wk since 24-28 wk of gestation. The primary outcomes were changes in theglucose homeostasis, including fasting plasma glucose, the 2-hr post prandial bloodglucose, serum insulin level, glycosylated hemoglobin (Hb A1C), and the homeostasismodel assessment of insulin resistance(HOMA_IR) at the initial period and 3 monthsafter intervention.Results: The mean maternal age of the patients who took selenium supplements was29.19 ± 6.16 (range 18-41) years. In the placebo group, the mean maternal age was 31 ±4.43 (range 24-39) years. Compared with the placebo group, fasting plasma glucose, 2-hr post-prandial blood glucose, glycosylated hemoglobin(Hb A1C), serum insulin level,and homeostasis model of assessment-estimated insulin resistance(HOMA_IR) werenot significantly changed in the selenium group at the end of study (p = 0.25, p = 0.87,p = 0.34, p = 0.57, and p = 0.31, respectively).Conclusion: The results of this trial suggest that supplementation with 100μg ofselenium does not modulate glucose homeostasis in women with GDM.

کلمات کلیدی:
Diabetes, Gestational, Selenium

صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/1005285/