Effect of Repetitive Transcranial Magnetic Stimulation on response inhibition by bilateral protocol in patients with Depressive Disorder

Background and Aim : Depression is one of the most prevalent psychiatric disorders and repetitive transcranial magnetic stimulation (rTMS) is a novel, safe and non invasive therapeutic tool for neuropsychiatric disorders such as depression but efficiency of this intervention on cognitive functions such as response inhibition of depressed patients is not clear. Neuro imaging studies have demonstrated that low function of left dorsolateral prefrontal cortex (LDLPFC) and high function of right dorsolateral prefrontal cortex (RDLPFC) have correlation with depression. Thus the purpose of the present study was to investigate the effect of bilateral protocol on response inhibition in depressive disorder.Methods : The participants were 12 patients with depressive disorder aged 25-45 years who were randomly selected from clients referred to Asayesh Neurotherapy Center. The experimental protocol was stimulation of left DLPFC (20Hz, 5s, 1400 pulses and 85% of MT) and inhibition of right DLPFC (1Hz, 10s, 700 pulses and 110% of MT. In all subjects, response inhibition was assessed by Go-No Task .Intervention was performed in 10 sessions during two weeks and then post-test was done.Results : Data were analyzed by SPSS software using paired t-test. The results showed the significant increment in number of correct responses in response inhibition after 10 sessions .no significant differences in reaction time was observed.Conclusion : To sum up, bilateral DLPFC rTMS was effectively associated with increment in number of correct responses in response inhibition functions during 10 sessions. Nevertheless, more controlled studies will be necessary to specify the long lasting effects of rTMS.

کلیدواژه ها:

Repetitive Transcranial Magnetic Stimulation (rTMS) ، DLPFC ، Response inhibition ، Depressive Disorder