HN-02520284_Cryolipolysis as A Non-Invasive Method for Body Contouring and Subcutaneous Fat Reduction

Introduction: Body-sculpting, including cryolipolysis has gained popularity for localized obesity. In cryolipolysis subcutaneous fat tissue is destroyed by controlled cooling based the hypothesis that adipocytes are more susceptible to cooling than surrounding tissues. The aim of this review was to evaluate the effect of cryolipolysis on subcutaneous fat reduction in flank, abdomen, arm, thigh, back, chin, knees and male breast and its safety, side effects, patient satisfaction and long-term results.Methods: This review was conducted on published articles in medical databases including Medline, Scopus, Web of Science, and Google Scholar during the years 2009-2019. The keywords included Cryolipolysis, fat reduction, body contouring, subcutaneous fat, cosmetic procedure, thermal injury, body sculping, cold induced fat loss, lipid profile and liver tests.Results: Nitenty-thre articles, 22 reviews and 6 systematic reviews were reviewed. In a report (n=42) reduction ininner thigh fat and circumferential measurements were 2.8mm and 0.9cm respectively in ultrasound assessment. Fat reduction in the flank after 2 and 6 months were 20% and 25% respectively. Another study (n=60) showed 2-5mm reduction in submental fat layer, 83% satisfaction and 80% tendency to recommend procedure to others and 77% visible fat reduction. Side effects included erythema, edema, bruising, transient neuralgia and delayed onset painin one female in a study (n=528), which resolved within 14 days after treatment.Conclusions: Cryolipolysis is a promising noninvasive method for body contouring with a limited side effect, that resolve without intervention, and high patient satisfaction, which results in significant localized fat reduction.