HN-01800194_Protective Effects of Propolis Supplementation on Hepatic Steatosis and Fibrosis among Patients with Nonalcoholic Fatty Liver Disease: A Randomized Clinical Trial

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 380

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شناسه ملی سند علمی:

ICNC03_117

تاریخ نمایه سازی: 12 اسفند 1398

چکیده مقاله:

Introduction: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, while no drugs have been approved for its treatment. The pieces of evidence indicate that propolis as a novel anti-inflammatory agent might be a promising candidate to treat NAFLD. The current study aimed to evaluate the efficacy of propolis on NAFLD.Methods: This randomized clinical trial was conducted on 54 patients with NAFLD. Patients with randomly assigned to receive propolis tablets at a dose of 250 mg twice daily for 4 months or placebo. The improvement in hepatic steatosis and fibrosis was evaluated using two-dimensional shear wave elastography.Results: The odds of improvement in the hepatic steatosis was significantly higher in the propolis group than the placebo group (5.84; 95% CI: 1.43 to 23.8; P=0.014), even after the adjustment for confounding factors. A significant reduction was observed on the liver stiffness in the propolis group (-0.65±0.56 kPa; P=0.001), whereas it increased in the placebo group (0.27± 0.59 kPa; P=0.037). Also, the intake of propolis significantly decreased hs-CRP levels compared with the placebo group (-0.37 mg/dL; P=0.01).Conclusion: The intake of propolis has protective effects on hepatic steatosis and fibrosis and the risk of cardiovascular disease in patients with NAFLD.

کلیدواژه ها:

Non-alcoholic fatty liver disease ، Steatosis ، Fibrosis ، Liver stiffness ، Propolis

نویسندگان

Davood Soleimani

Department of Nutritional Sciences, School of Nutritional Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran- Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Mitra Rezaie

Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Farnood Rajabzadeh

Department of Radiology, Mashhad Medical Sinences Branch, Islamic Azad University, Mashhad, Iran

Mohammadreza Abbaspour

Targeted Drug Delivery Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

Mostafa Saedi

Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Jamshid Gholizadeh Navashenaq

Immunology Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran