HN-01140067_MicroRNA: The New Ubiquitous Parameter for Children Overweight

Introduction: DNA down-regulation occurs at the prenatal materials and develops childhood obesity. MicroRNA, as the bandmaster of genetic sector, is the regulator for the development of obesity. According to the Iranian statistical information, waist circumference of children has significantly increased recently. Childhood obesity has provoked major problems for children at present and in future as they become susceptible for chronic diseases and consequent health problems.Methods: Articles published from 1986 up to 2018 for the subject were searched in the PubMed.Discussion: Childhood obesity is the result of down-regulation in uterus environment and parent’s microRNAs in the genetic sector. Three microRNAs, 486, 146b, and 15 microRNAs, have been assessed more frequently in studies on children with overweight and fatness.Conclusion: Identifying the real cause of childhood obesity seems to be related to microRNA. MicroRNAs can be a target for new treatment methods. Molecular nutrition can be a new way for dietary management to properly control and treat obesity in children.

کلیدواژه ها:

Child ، Down-regulation ، Food ، Gene ، MicroRNA ، Obesity