HN-01050090 _The association of omentin gene expression in visceral and subcutaneous adipose tissue with plasma fatty acids profile and dietary fatty acids

Introduction: Omentin is an adipokine, which has anti-inflammatory effects and reduces insulin resistance, hence, it can play an important role in prevention of cardiovascular disease and diabetes. The present study aimed to investigate the association of plasma and dietary fatty acids with the gene expression of omentin in visceral and subcutaneous adipose tissues.Methods: Visceral and subcutaneous adipose tissues and fasting blood were gathered from 50 obese and 47 non-obese participants, who had undergone elective abdominal surgery. Dietary intakes were assessed using a food frequency questionnaire. The relative gene expression of omentin in visceral and subcutaneous adipose tissues was measured by Real-Time PCR and plasma fatty acids was measured using gas chromatography.Results: Omentin gene expression was higher in non-obese participants compared to obese ones in visceral adipose tissue; however, no difference was found in subcutaneous adipose tissue. A significant direct association was observed between omentin gene expression in visceral adipose tissue with dietary monounsaturated fatty acid (MUFA) (P=0.011, β=0.394) in obese subjects and plasma omega 6: omega 3 ratio (P=0.029, β=0.385) in non-obese subjects after adjustment for confounders. No association was observed between omentin gene expression in subcutaneous adipose tissue and plasma and dietary fatty acids.Conclusion: Dietary intake of MUFA in obese participants and plasma omega 6: omega 3 ratio in non-obese ones were directly associated with omentin gene expression in visceral adipose tissue. Therefore, higher omentin gene expression through increasing dietary MUFA may be related to improvement of obesity and its associated comorbidities.

کلیدواژه ها:

Omentin ، Saturated fatty acids ، Monounsaturated fatty acids ، polyunsaturated fatty acids ، omega-6: omega-3 ratio ، Visceral adipose tissue ، Subcutaneous adipose tissue