HN-00430013_The Effect of Intramuscular Mega dose of Vitamin D Injections on E-Selectin, CRP and Biochemical Parameters in Vitamin D-Deficient Patients with Type-2 Diabetes Mellitus: A Randomized Controlled Trial

  • سال انتشار: 1398
  • محل انتشار: سومین همایش بین المللی تغذیه بالینی ایران
  • کد COI اختصاصی: ICNC03_049
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 484
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نویسندگان

Farhang Mirzavandi

Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran- Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Nasir Talenezhad

Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran- Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Hassan Mozaffari-Khosravi

Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran- Yazd Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

چکیده

Introduction: Inflammatory processes has been shown to be associated with the development of type 2 diabetes mellitus (T2DM) in which vitamin D supplementation might exert beneficial outcomes. We examined the effects of vitamin D supplement on inflammatory and cell adhesion molecule in patients with T2DM.Methods: This study consisted of 50 patients with T2DM who had vitamin D deficiency. Participants were randomized into two groups of 25 in which the intervention group received two intramuscular injections of a 200000-IU vitamin D supplement, one at week 0 and another at week 4. The concentrations of fasting blood glucose (FBG), lipid profiles, liver enzymes, E-selectin, C-reactive protein (CRP), calcium, phosphorus, serum 25-hydroxyvitamin D [25(OH)D] and anthropometric indices were obtained before and after 8 weeks.Results: Vitamin D resulted in significant reductions in CRP(P=0.01) and gamma glutamyl transferase (GGT) levels(P=0.03) and significant increases in 25(OH)D concentrations(P=0.01) in the intervention group compared with the control. Within-group comparisons showed that FBG decreased significantly in the intervention group (P= 0.04). No significant changes were observed regarding within- and between-group comparisons of the other markers.Conclusion: Vitamin D had beneficial effects on the levels of CRP, serum 25(OH)D and GGT among vitamin D deficient patients with T2DM. (http://www.irct.ir: IRCT2017100336539N1).

کلیدواژه ها

Vitamin D, Type 2 diabetes mellitus, E-selectin, Randomized controlled trial

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