Perioperative Pain: Molecular Mechanisms and Future Perspectives
سال انتشار: 1396
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 396
فایل این مقاله در 8 صفحه با فرمت PDF قابل دریافت می باشد
- صدور گواهی نمایه سازی
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_SBMU-2-3_001
تاریخ نمایه سازی: 6 اسفند 1398
چکیده مقاله:
Background: Acute perioperative pain is seen in more than 80% of patients undergoing surgery, with almost 75% of them experiencing moderate, severe, or extreme pain; adequate postoperative pain management is not achieved in a satisfactory manner. This styudy was desined ana performed to assess the molecular mechanisms of acute pain management in order to find novel future perspectives.Materials and Methods: In this narrative review, molecular mechanisms of currently available pain controlling agents were assessed based on 3 steps: preoperative, intraoperative and postoperative phases. Drugs used in each phase and potential novel agents were assessed separately.Results: many currently available clinical agents were discussed and meanwhile, other potential drugs that could be among the future choices are discussed.Conclusion: cellular and molecular medicine could open new windows in order to discover novel agents for management of pain; we will have possibly many new agents that will be available in future while they will be different from currently used clinical pain killers.
کلیدواژه ها:
نویسندگان
Zahra Talebi
Cardiac Anesthesiology Department, Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Ali Dabbagh
Cardiac Anesthesiology Department, Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran