The Efficacy of Vitamin D3 as Adjuvant Therapy in Control of Drug Resistant Epilepsy

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 476

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تاریخ نمایه سازی: 28 بهمن 1398

چکیده مقاله:

Background: Drug-resistant epilepsy (DRE), also known as refractory epilepsy (consist of 25% of epileptic patients), is defined as failure of trials of two antiepileptic drugs (AED schedules) to achieve sustained seizure freedom. Vitamin D3 is the form of vitamin D called cholecalciferol. Calcitriol is a synthetic physiologically-active analog of vitamin D, specifically the vitamin D3 form. The aim of this study was to assess the efficacy of Vitamin D3 as an adjuvant therapy in reducing the seizure frequency of patients with drug resistant epilepsy. Method: On hundred and fourteen patients (18-70 years old age) with drug resistant epilepsy were assessed for this double blind-clinical trial study between 2018-2019. First, Serum level of vitamin D3 were measured and those Patients with normal serum level of Vitamin D3 were excluded from study. Those with low serum level were enrolled in the study and divided randomize in two groups. First group were received anti-epileptic drugs (AEDs) and oral Vitamin D3 (6000 IU/day for 8 weeks and then 3000 IU/day as a maintenance dose) and the second group were followed as a control group and just received AEDs. Patients were followed for 3 months and seizure frequency before and after this trial were compared between two groups. Kolmogorov –Smirnov method was used for statistical analyzing of the data. As the data distribution was normal, independent T-test was used. Result: Forty-four patients (22 males & 22 females) had low serum vitamin D3. The average age was 33.5 years. The frequency and duration of seizures reduced in those patients received vitamin D3 more than those patients received placebo but this comparison was not significant (P= 0.123). There was a significant difference between two groups and seizure frequency were reduced more than 50% in patients received vitamin D3 as an adjuvant therapy. Discussion: This case –controlled study was done on forty-four adult uncontrolled epileptic patients. Epileptic patients randomize divided two groups. The case group received AEDs with vitamin D3 and the controlled group placebo with AEDs. These patients followed three months for frequency of seizure relapse. Although epileptic attacks is reduced with vitamin D3 as adjunct therapy but not significant.Conclusion: In our study the frequency and duration of epileptic attacks were reduced in patients received AEDs with vitamin D3 in compare only AEDs but it was not significant.

کلیدواژه ها:

Drug resistant epilepsy- Adjunct therapy- Vitamin D3


Mohammad Reza Najafi

Professor of Neurology

Jaafar Mahvari

Associated of Neurology

Mohammad Zare

Medical of student Department of Neurology, affiliation IUMS

Farnoush Sattari

Medical of student Department of Neurology, affiliation IUMS