Evaluation of Vancomycin, Caspofungin, Linezolid and Amphotericin B Use in Ayatollah Taleghani Hospital

Introduction: Bacteria have become resistant to antibiotics as a result of bacteria s genetic changes, and extensive use and prescription of these medications in community and hospitals have exacerbated the threat. Many complications will occur due to antimicrobial resistance so it s vital to take action against that. This study aimed at investigating the correctness and reasonability of prescription of four antimicrobials in Ayatollah Taleghani hospital. Method: Cross-sectional prospective study was conducted in Taleghani Hospital, Tehran, Iran. Totally 121 patients from 3 wards of Intensive Care Unit, general surgery and vascular surgery, with a variety of underlying diseases, entered the study during 3months of follow up. The information about frequency, duration of treatment, indication and dose of four antimicrobial (Vancomycin, Caspofungin, Linezolid, and Amphotericin B) were obtained based on the information of the physician and nursing records in addition to laboratory findings, as well as the collected information from Hospital Information System. Results: In the Intensive care unit, the most prevalent antibiotics were Vancomycin (90%) and Caspofungin (10%); in vascular surgery unit, Vancomycin (88.89%) and Caspofungin (11.11%) has high rate of administration and finally in general surgery ward Vancomycin (100%) and Caspofungin (0%) was the most common type of antibiotics. This study showedantibiotic Therapy was started for 61.16% patients based on empiric therapy, and microbiological cultures were utilized only for 38.84% of the patients. Conclusion: The result of this study has shown a high rate ofantibiotic use, which is not based on antimicrobial culture. It is vital to have medical interventions and professional training for physicians in order to reduce the unnecessary use of antibiotics. Appropriate useof antibiotics could be promoted by the use of an Antibiotic Stewardship Program (ASP’s). References: Salehifar E, Babamahmoodi F, Alikhani A, Ganji R, Fazli M. Drug Utilization Evaluation of Vancomycin in a Referral Infectious Center in Mazandaran Province. J Pharm Care. 2(2):55-59. Hamishehkar, H., et al. (2015). Drug Utilization Evaluation of Vancomycin in a Teaching Hospital in Tabriz-Iran. Pharm Sci 21(1): 25-29. Ayubi MS, Elyasi S, Jannati M, Vahdati-Mashhadian N, Saberi MR, Naderi HR, Mohammadpour AH. Vancomycin Utilization Evaluation in a Tertiary Teaching Hospital in Mashhad, Iran.

کلیدواژه ها:

Antibiotic Stewardship Program ، Antibacterial agents ، Drug Resistance ، Caspofungin ، Vancomycin