Symptomatic uterine myoma and treatment methods

Background and Aim : uterine leiomyomata is a common and benign connective tissue tumor.Theprevalence is 30% of all women . leiomyomas is the most important reason of abnormal uterine bleedingthat is still a common indication for myomectomy or hysterectomy in the world. The aim of this study isComparison of two groups of drugs in treatment of symptomatic uterine myoma and the need to use surgicalprocedure.Methods : this is a comparative clinical trial on 48 women with symptomatic uterine leiomyomataaccompany vaginal bleeding referred to Dr.rasekh clinic, Iran .Diagnosis was performed based on clinicalsymptoms, pelvic examination and ultrasonography. patients randomly divided in two groups : 24 patientsin control group treated with Dydrogesterone and 24 patients in case group gonadotropin- releasinghormone agonist(Triptorelin acetate) for 6 months. Data collection was performed via questionnaires andstatistical analysis by SPSS 21.Results : There is no significant difference between mean size of the myoma before intervention in caseand control groups.Mean myoma size is not significant difference in Dydrogesterone usage (control group)before and at the end of six months intervention. But the mean of myoma size is significant difference inTriptorelin acetate usage (case group)before the intervention 56.45 ± 5.84 and after intervention 50.06 ±5.30 ( pvalue≤.05 ) that represents a significant reduction of myoma size. Clinical bleeding symptomsimproved in both groups which indicate response to treatment.Conclusion : Due to the complications of surgical procedures and the results of this research shows thatthere is a significant decrease in myoma size and response to treatment in Triptorelin acetate usage.Therefore , surgical procedure is not necessary. Medical therapy is recommended as the first choice ofmyoma treatment .

کلیدواژه ها:

leiomyomas ، Triptorelin acetate ، Dydrogesterone ، treatment methods