Inhibition of mouse colon cancer growth following immunotherapy with hydatid cyst fluid and BCG

Introduction and Objectives: Hydatid cyst located in human and livestock viscera is the larval stage of Echinococcus granulosus tape worm. Scientific evidences indicating that certain Parasitic Infections may induce antitumor activities against some types of cancers. In this research work, the effects of a hydatid cyst fluid and BCG on colon cancer tumor growth in BALB/c mice have been studied. Materials and methods: For this purpose, four groups of mice were injected with colon cancer cells. After 5 days when the sign of tumor growth in mice was seen, group 1&2 were injected with hydatid cyst fluid and BCG respectively. Groups three were injected with only adjuvant and the fourth group left intact without any injection. The size of the tumor was measured and compared in all groups. Then blood samples of mice were evaluated for serum cytokine levels. Results: In mice injected with hydatid cyst fluid and BCG tumor size were smaller than those of control groups and the difference was statistically significant.Conclusion: The results of this work indicated that injection of a hydatid cyst fluid and BCG significantly inhibited mouse colon cancer growth and this inhibition may be related to effect of immune response to these antigens.

کلیدواژه ها:

Colon cancer ، cytokine ، Echinoccocus granolosus ، hydatid cyst fluid ، BCG