Production, quality control and biological evaluation of 153Sm-TTHMP as a possible bone palliation agent

سال انتشار: 1390
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 278

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شناسه ملی سند علمی:

JR_IRJNM-19-2_008

تاریخ نمایه سازی: 21 بهمن 1398

چکیده مقاله:

Introduction: Various bone palliative therapeutic agents have been developed and widely used for bone metastasis such as 153Sm-EDTMP. In this study, production, quality control and biodistribution studies of a newly developed therapeutic compound have been presented followed by imaging studies in wild-type rodents. Methods: 153Sm-TTHMP was prepared starting from 153Sm-SmCl3, prepared by neutron activation of an enriched 152Sm sample (purity > 98%), and in-house synthesized TTHMP in 1h at 25°C followed by stability tests, partition coefficient determination and biodistribution studies of in wild-type rodents using scarification and SPECT imaging. Results: The radiolabled Sm complex was prepared in high radiochemical purity (> 99%, ITLC) and specific activity of 278 GBq/mmol and demonstrated significant stability at 4, 25 and 37°C (in presence of human serum). Initial biodistribution data showed significant bone accumulation of the tracer in 48h. Conclusion: 153Sm-TTHMP can be a potential candidate for bone pain palliation therapy in skeletal metastases, although further biological studies in other mammals is still needed.

نویسندگان

Zohreh Naseri

Inorganic Chemistry Department, Faculty of Sciences, Tehran University, Tehran, Iran

Amir Reza Jalilian

Radiopharmaceutical Research and Development Lab, Nuclear Science and Technology Research Institute, Atomic Energy Organization of Iran, Tehran, Iran

Ali Nemati Kharat

Inorganic Chemistry Department, Faculty of Sciences, Tehran University, Tehran, Iran

Ali Bahrami-Samani

Radiopharmaceutical Research and Development Lab, Nuclear Science and Technology Research Institute, Atomic Energy Organization of Iran, Tehran, Iran