Radioimmunotherapy-based treatment of cancer

سال انتشار: 1391
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 463

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شناسه ملی سند علمی:

JR_IRJNM-20-1_009

تاریخ نمایه سازی: 21 بهمن 1398

چکیده مقاله:

The principle of cancer immunotherapy includes various methods of manipulations to influence immune responses against tumors in both humans and animals. This advanced technology of hybridoma production provided the necessary skills to efficiently produce highly specific monoclonal antibodies (mAb). Radioactively-tagged antibodies which are applied in radioimmunotherapy (RIT), can target adjacent cells and may not require immune function. This study highlights the mechanism and the effect of action of radioimmunotherapic agents, especially two applied agents including 90Y-ibritumomab tiuxetan and 131I-tositumomab that are approved by Food and Drug Administration (FDA) for treatment of some cancers.

نویسندگان

Shokrollah Farrokhi

Department of Immunology and Allergy, Faculty of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran and Department of Immunology and Allergy, The Persian Gulf Tropical and Infectious Diseases Research Centre, Bushehr University

Mohammad Ravanbod

Department of Immunology and Allergy, The Persian Gulf Tropical and Infectious Diseases Research Centre, Bushehr University of Medical Sciences, Bushehr, Iran

Shahram Amiri

Department of Immunology and Allergy, Faculty of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran and Department of Immunology and Allergy, The Persian Gulf Tropical and Infectious Diseases Research Centre, Bushehr University

Iraj Nabipour

Department of Endocrine and Metabolic Diseases, The Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, Iran

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