The Frequency of PlA2 Gene among Iranian Population

Background: It is demonstrated that there is a relation between rs5918 on Integrin GPIIIa gene (integrin beta 3) and the possibility of platelet aggregation, coronary artery occlusion, stent thrombosis or lower reactivity to antiplatelet drugs – aspirin and clopidogrel or inhibitors of GPIIb/IIIa. The aim of present study was to determine the frequency of the polymorphism on the ITGB3 gene in a sample population of Iranian patients with atherosclerosis.Method: fifty-two referred patients to Rajaie Cardiovascular Hospital with the average age of 59 were included in this study. The GPIIIa PlA1/A2 polymorphism (rs5918) determined in all samples using PCR based restriction fragment length polymorphisms (RFLP) for genotyping.Results: according to the obtained results, the frequency of T allele was higher in comparison with other allele. The frequency of TT genotype, heterozygote CT and CC genotype have been calculated around 81%, 17.3% and 0.9%, respectively.Conclusion: We demonstrated that these genotypes for the mentioned SNP are in Hardy-Weinberg Equilibrium (HWE). Likewise, similar to previous studies among other populations including Turkish, Slovenia, Chinese and Austrian populations, the T allele is the most common specified allele for this polymorphism. Further studies would be helpful for clinical management the patients with atherosclerosis who receiving Plavix (clopidogrel)

کلیدواژه ها:

GPIIIa PlA1/A2 polymorphism ، Clopidogrel