Alternative Splicing of EXT1 Gene in Breast Cancer cells
سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 408
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شناسه ملی سند علمی:
CIGS15_640
تاریخ نمایه سازی: 13 بهمن 1398
چکیده مقاله:
Breast cancer is the most commonly diagnosed cancer and the fifth leading cause of cancer-death in women. Since the peak incidence age of Iranian women is a decade younger than that of the word, it is necessary to elucidate the mechanisms involved in the tumorgenesis of breast cancer and discover novel diagnostics markers, specific for Iranian population. The EXT1 gene is located in 8q24.11 and its only protein coding transcript encodes exostosinglycosyltransferase1 which has a vital role in intercellular connections. It has been suggested both tumor promoting and tumor suppressor role for the gene. Due to its 48.13% amplification in breast cancer, investigation of its alternatively spliced variants is important. Here, we are reporting the existence of some alternatively spliced form of the gene, with potential involvement in breast tissue tumorihgenesis.
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نویسندگان
Saba Abbassioun
Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
Nasim Ghorbanmehr
Department of Biotechnology, Alzahra University, Tehran, Iran
Seyed Javad Mowla
Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran